DetermiNatioN of trifluoroacetic acid iN tropisetroN HydrocHloride by ioN cHromatograpHy
ZHOU Chuan-jing
SONG Yu-ping
LI Yu-shuang
WEI Chang-feng
Abstract：Objective To develop an ion chromatography method for the determination of trifluoroacetic acid in tropise-tron hydrochloride. MetHods The method uses an Ionpac AS11-HC column(4 mm × 250 mm)and a guard column(4 mm × 50 mm),taking mixture of 4. 5 mmol·L-1 sodium carbonate and 0. 8 mmol·L-1 sodium hydrogen carbonate solution as eluent at a flow rate of 1. 2 mL·min-1 . The cell heater temperature was 35℃,column temperature was 35℃ and injection volume was 25 μL. Results There was a good resolution between trifluoroacetic acid and other components. The linear range of trifluoroacetic acid was 0. 261 3~8. 711 3 μg·mL-1(r=0. 999 9). LOD was 0. 086 2 μg·mL-1,and LOQ was 0. 261 3 μg·mL-1. CoNclusioN This method had good specificity and sensitivity. It can be used to detect trifluoroacetic acid in tropisetron hydrochloride.
Keywords：Tropisetron hydrochlorideIon chromatographyTrifluoroacetic acid
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 635-636,639 )