Real - time online monitoring the dissolution of Montelukast Sodium Tablets by fiber - optic dissolution test system
WANG Li
CHEN Xiao-wei
HAO Gui-zhou
Abstract：Objective To monitor the instantaneous dissolution of montelukast sodium tablets by fiber - optic dissolu-tion test system and comparison with state standard test method. Methods The dissolutions of six tablets were determined simultaneously with FODT - 601 fiber - optic medicine dissolution system. The interference of excipients was cancelled by two wavelengths 284 / 500 nm. The stripping curves were completed according to dissolution conditions of existent standard for dissolution detection,and compared the stripping curves. Results The calibration curve was linear in the range of 1. 0~ 12 μg·mL - 1(r = 0. 999 3). The average recoveries of three concentration were 99. 3% ,98. 9% ,98. 5% ,with corre-sponding RSD of 0. 86% ,1. 02% ,0. 91%(n = 18),respectively. Conclusion Compared with the state standard,the fiber- optic dissolution test system is capable of monitoring the real dissolution process of drug,and it was better to provide the efficient way for the drug productive technology and inherent quality.
Keywords：Montelukast sodium tabletsDissolutionFiber - optic dissolution test system
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 571-573 )