The study on dose - effect relationship about anti - tumor activity of Lentinan for Injection
LI Xue-mei
HU Yu-chi
Abstract：Objective To observe the effect about different concentration of Lentinan for Injection on mouse tumor in-hibitory which was implant sarcoma 180 cells by subcutaneous administration and dose - effect relationship. Methods ICR mice were implant 3. 6 × 106 sarcoma 180 cells by subcutaneous groin,then each mouse was injected 0. 1 mL different con-centration solution of Lentinan for Injection(0. 250 0,0. 125 0,0. 062 5,0. 031 3,0. 015 6,0. 007 8 mg·mL - 1 )by intrap-eritoneal administration. The mice were injected Lentinan Solution for Injection 5 days continually,then stop 1 day,mice were injected again for 5days continually. Mice were killed who was implanted sarcoma 180 cells after 18 days,tumour was weighted. Results The mice' s tumour weight in Lentinan for Injection groups significantly lower than model control group. When the concentration between 0. 007 8 mg·mL - 1 and 0. 250 0 mg·mL - 1 ,the correlation coefficient of linear re-gression equations between logarithm of concentrations and tumor inhibitory rate were 0. 956,0. 962,0. 978,respective-ly. Conclusion Lentinan for Injection had antitumor action. There were linear relationships between logarithm of concentra-tions and tumor inhibitory rate.
Keywords：Lentinan for InjectionTumor inhibitory rateDose - effect relationship
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 564-566,573 )