The clinical effect of dexmedtomidine at ease the patients' stress respond around the time of tube drawing in thoracoscope surgery with general anesthesia

ZHANG Yong; WANG Yao-qi; GAO Tian-qin; JING Guang-jian; ZHANG Li

Abstract：Objective Discusses the clinical effect of dexmedtomidine at ease the patients' stress respond around the time of tube drawing in thoracoscope surgery with general anesthesia. Methods Choosing 60 cases of surgical patients ac-cepting the double cavity tracheal intubation surgical operation under the condition of general anesthesia(ASA Ⅰ ~ Ⅱlev-el),the 60 cases are divided into two groups:Dex group is the patients who took DEX(Dex 0. 5 μg·kg - 1 ,n = 30)and Comparison group is the comparison group(physiological saline 10 mL,n = 30). Recording the patients' heart rate(HR), respiring rate(RR),systolic pressure(SBP),diastolic pressure(DBP),average arterial pressure(MAP),the index of brain electricity double frequency spectrum before the anesthesia,before using medication,during the corresponding time points. Recording Norepinephrine(NE)in blood,adrenaline(E)density before anesthesia,aspiration of sputum,at the time of de-cannulation,2,6 minutes after the decannulation as well as the grade of vigilance and calmness 2,4,6,10,15 minutes after extubation. Results Compared with comparison group,blood pressure and heart rate of Dex group is steady before decannu-lation,the rising degree of norepinephrine and adrenaline density was less obvious during the period of inner catheter aspira-tion sputum. The same result occurs to SBP,DBP,MAP,HR 2,4 minutes after the decannulation. The level will come back to the normal degree before the decannulation 10 minutes after the operation,there being a statistic significance comparing the research results between these 2 groups(P ﹤ 0. 05). Conclusion Dexmedtomidine can ease the patients' stress respond obviously around the time of tube drawing in thoracoscope surgery with general anesthesia.