Anti - inflammatory effect of chlorogenic acid on adjuvant arthritis rats

XU Ying-hui; SHEN Ru; LIU Yan-yan

Abstract：Objective To investigate the effects of the anti - inflammatory effect of chlorogenic acid on adjuvant arthri-tis rats. Methods Treated with various concentrations of chlorogenic acid on adjuvant arthritis(AA),then divided into six groups as control group,model group,positive control group(nimesulide),low dose(25 mg·kg - 1 ),medium dose(50 mg· kg - 1 )and high dose(100 mg·kg - 1 )of chlorogenic acid to observe the effect of chlorogenic acid on adjuvant arthritis model rats with left and right foot plantar width,serum tumor necrosis factor(TNF - alpha),interleukin 2(IL - 2),the a-mount of circulating immune complex(CIC),superoxide dismutase(SOD),glutathione peroxidase(GSH - Px)and malon-dialdehyde(MDA)content. Results The results demonstrated that chlorogenic acid(25 mg·kg - 1 and 100 mg·kg - 1 ) can inhibit rat ear swelling caused by dimethylbenzene and foot swelling caused by freund's adjuvant. Chlorogenic acid in medium dose group(50 mg·kg - 1 )and high dose group(100 mg·kg - 1 )could reduce the content of increase SOD and GSH - Px level,compare the difference was statistically significant(P ﹤ 0. 05). Conclusion The results demonstrated that chlorogenic acid had anti - inflammatory effect on adjuvant arthritis(AA)and by reducing the TNF - α,IL - 2,CIC and MDA content and increasing antioxidant capacity.