The synthesis of imipenem
WU Hong-ying
SUN Xiu-ling
BAI Wen-qin
Abstract：Objective To synthesize imiPenem. Methods ImiPenem was PrePared from bicyclic keto ester,reacting with cysteamine hydrochloride after PhosPhrylation,then through the reaction of condensation,and catalytic hydrogenation. Results The Process had been successfully imPlemented to PrePare the target comPound in 62% overall yield and 98. 6% area Purity. Conclusion This Process was more suitable for industrial Production with simPle oPeration,high Purity and high yield.
Keywords：ImiPenemSynthesisCondensationCatalytic hydrogenation
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 492-493 )