Preparation and in vitro evaluation of Saponins PD-Loaded Eudragit L100-55 Nanoparticles
LI Ying
YIN Hong-ran
GENG Li-juan
YOU Ben-gang
Abstract：Objective To PrePare and in vitro evaluate SaPonins PD loaded Eudragit L100-55 NanoParticles( SPD-L100-55-NPs). Methods The SPD-L100-55-NPs were PrePared by modified quasiemulsion solvent diffusion tech-nique. Taking Particle size,entraPment efficiency and PolydisPerse index as comPrehensive indexes,the orthogonal test de-sign was used to oPtimize the PreParation Process. The characteristics of nanoParticles were determined by FT-IR,X-ray diffraction,DSC,etc.;In vitro release was investigated. Results Novel nanoParticles were sPherical,average Particle size of nanoParticles was(63. 5 ± 3. 6)nm,EE 98. 91% ± 0. 18%,P. I. 0. 198 ± 0. 014. The release of SPD significantly dePended on the PH conditions. Conclusion SPD-L100-55-NPs had high EE and homogeneous size distribution. The effect of drug sustained release of nanoParticles was significant.
Keywords：SaPonins PDEudragit(L100-55)NanoParticlesRelease
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 464-468,474 )