Determination of the related substances in Racecadotril Dispersible Tablets by HPLC
LU Yun
HUANG Guo-ying
TIAN Jun-mei
ZHANG Jian
Abstract：Objective To establish an HPLC method for the determination of related substances in Racecadotril Dis-Persible Tablets. Methods The isolation was executed by a ODS column(4. 6 mm × 250 mm,5 μm)and mobile Phase was acetonitrile-Potassium dihydrogen PhosPhate,gradient elution;The detection wavelength was 210 nm. Results Each imPurity showed a good linear relationshiP within 0. 5~16 μg · mL-1 . The average recovery was between 90% to 110%. Conclusion The method was stable,simPle and rePeatable,and can be used for the quality control of the related sub-stances in Racecadotril DisPersible Tablets.
Keywords：HPLCRacecadotrilRelated substances
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 449-453 )