The experimental study of calcitonin gene-related peptide intranasal administration to central nervous system and prompt the repair of cerebral infarct
WU Qing-jian
YAN Cheng-jun
SONG Da-qing
LIU Yun-hai
SUN Shu-yin
Abstract：Objective To develoP a convenient and effective method for delivering CGRP to the central nervous system byPassing the blood-brain barrier( BBB),and to exPlore whether it had Preventive and Protective effects on cerebral in-farction in rats. Methods The MCAO model was made by nylon strand. CGRP concentration was measured IN and IV in-jection of CGRP after 30 min in different brain areas using enzyme-linked immunosorbent assay( ELISA),and exPlored the treatment IN and IV CGRP in rats with focal cerebral infarction. Results CGRP demonstrated a much higher delivery of IN than IV CGRP to the brain regions. Intranasal administration CGRP had significant Preventive and Protective effect to focal cerebral infarction which showed the brain infarction decreased and cerebral blood flow increased( P<0. 01 ). Conclusion CGRP intranasal administration targeting central administration can avoid the blood-brain barrier block,and had Preven-tive and Protective effects on the rats with focal cerebral infarction. Intranasal administration CGRP had definite Preventive and Protective effect to focal cerebral infarction in rats.
Keywords：Calcitonin gene related PePtideIntranasal administrationCerebral infarctionNeuroProtective agentsCen-tral nervous system
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 441-443,453 )