Effects of different penetration enhancers on transdermal absorption of ginsenoside Rg1 in vitro
HAN Li
WANG Ping
LIU Shan-xin
SU Ming
SUN Hu
Abstract：Objective To investigate the effects of different penetration enhancers on transdermal absorption of ginsen-oside rg1 in vitro through skin - penetrating experiments in mice,and determine the best penetration enhancer for laying the foundation for researching new transdermal absorption preparations. Methods Using the modified Franz diffusion pool method,with mice skin as transdermal barrier,physiological saline as accept medium,adding different penetration enhancers to make samples,with ginsenoside rg1 as quantitative indexes for transdermal absorption in vitro tests,measured by high performance liquid chromatography( HPLC) method,inspects the accumulation of ginsenoside rg1 through the vol-ume. Results Without penetration enhancers,ginsenoside rg1 had no accumulation;In single penetration enhancers,7%propylene glycol had the best effect,7% azone came second,borneol in aqueous solution had more lower effect;In compound penetration enhancers,the accumulation of azone ﹢ propylene glycol groups was closing at any concentrations;Effect of azone﹢ borneol group was better when both concentrations were at 2. 5% . Conclusion Common penetration enhancers as azone,propylene glycol and borneol can increase the accumulation of ginsenoside rg1 ,among them,7% propylene glycol was the best.
Keywords：Ginsenoside rg1Transdermal absorption in vitroPenetration enhancer
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 391-394 )