The preliminary inquiry of liposomes reduce nimesulide liver toxicity
LIU Cong
CHEN Xin-mei
YUAN Yu-fang
Abstract：Objective To explore the influence of nimesulide liposomes to liver. Methods Methods of test animals were randomly divided into control group,nimesulide solution group and nimesulide liposome group. Each group were orally administered drugs accordingly,21 d after testing animals were sacrificed and liver tissue ALT and AST activity observed path-ological changes in Liver tissue. Results The nimesutide solution group of mice was compared with the control group of mice whose serum aspartate,alanine aminotransferase were significantly increased,respectively(250. 11 ± 31. 64),(234. 01 ± 29. 59),P ﹤ 0. 01;Mice with liposome and solution mice compared to their aspartate transaminase,alanine aminotransferase were low,respectively(207. 33 ±25. 77),(198. 44 ± 24. 70),P ﹤ 0. 05;Microscopic observation of mouse liver biopsy,liver damage liposome group of mice was significantly lower extent. Conclusion Liposomes reduced liver toxicity nimesulide.
Keywords：NimesulideLiposomesLiver protection
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 382-383,398 )