Studies on chitooligosaccharide applicatied in solid dispersion of baicalin
ZHAI Wen-ting
SHI Hong-jun
Abstract：Objective To prepare the solid dispersion of baicalin,using chitooligosaccharide with the intention of im-proving drug dissolution. Methods Baicalin solid dispersion was prepared by spray drying method with chitooligosaccharide as carriers. The physical characteristics and in vitro dissolution of baicalin solid dispersion were further evaluated. Results Dissolution percentages of solid dispersion prepared in the drug-carrier ratio of 1:6 was 94. 25% at 30 min. The differential scanning calorimetry( DSC)and scanning electron microscopy( SEM),X-ray powder diffraction( XRD)demonstrated that baicalin existed in amorphous state. Fourier transform infrared spectroscopy( IR)results indicated presence of interactions between chitooligosaccharide and baicalin. Conclusion The results indicated that solid dispersion prepared with chitooligo-saccharide as carrier can significantly increase dissolution of baicalin. As a new type carrier of solid dispersion,chitooligo-saccharide had its practical value.
Keywords：BaicalinChitooligosaccharideSolid dispersionPhysical characterizationDissolution
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 341-344 )