Protective effect Yiqi Shengjin Huoxue Prescription on microvascular dysfunction of cardiac muscle in streptozotocin-induced diabetic rats
SONG Qin-lan
LIN Hai-qing
Abstract：Objective To investigate protective effect of Yiqi Shengjin Huoxue Presciption on streptozotocin-induced microvascular injury of cardiac muscle. Methods Sixty male SD rats were induced diabetic models by streptozotocin and randomly divided into six groups( n=10 in each):a normal control group,a diabetic control group,a metformin group,a Yiqi Shengjin Huoxue Prescription pretreatment group,two Yiqi Shengjin Huoxue Prescription treated groups. After treating diabetic rats by gavage of Yiqi Shengjin Huoxue Prescription,killed them and took blood from the abdominal vein and the homogenate of cardiac muscle. The levels of soluble intracellular adhesion molecule-1(SICAM-1),interleukin-1(IL-1),endothelin-1(ET-1)in cardiac muscle were determined by ELISA,and the blood glucose was measured by the glu-cose oxidase method. Results An increase in fasting blood glucose was observed in the rat model of diabetes when com-pared with normal control groups(P﹤0. 05),indicating the rat model of diabetes was established. The Yiqi Shengjin Huox-ue Prescription significantly reduced fasting blood glucose,decreased the levels of SICAM-1,IL -1 and ET-1 in cardiac muscle of diabetic rats(P﹤0. 05). Conclusion The Yiqi Shengjin Huoxue Prescription can improve glucose homeostasis and protect the microvascular of cardiac muscle in STZ-induced diabetes.
Keywords：Yiqi Shengjin Huoxue PrescriptionMicrovascular of cardiac muscleDiabetic rats
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 323-325 )