Micronucleus test of dehydroacetic acid in mice
LI Jia-chang
DU Yu-feng
SHI Yu-jing
Abstract：Objective To investigate mutational function of dehydroacetic acid( DHA). Methods The experimental animals were randomly divided into five groups such as negative control group,1/10 LD50 ,1/5 LD50 ,1/2 LD50 and positive control group,respectively. Ten animals were in each group,half male and female. The mice received DHA through gavage by 30 h method(24 h interval between 2 times). Sliders were made,polychromatic erythrocyte(PCE)was observed and rates of their micromucleus were counted an compared with positive and negative groups. Results Beside of 1/5 LD50 ,1/10 LD50 DHA groups,the 1/2 LD50 group was obviously different from normal mice(P﹤0. 05),but there were not dose-effect relationship within three doses of DHA groups. Conclusion The micronucleus test of DHA were observated a nega-tive result.
Keywords：Dehydroacetic acidMicronucleus testBone marrow cellsMice
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 319-320,325 )