Study on the effect of lipid chain length on the precipitation of crataegi folium flavonoids from supersaturatable self - emulsifying drug delivery system
ZHANG Huan-bin
OU Li-hong
CUI Sheng-miao
Abstract：Objective To evaluate the effect of lipid chain length on the precipitation of crataegi folium flavonoids from supersaturatable self - emulsifying drug delivery system(SEDDS)on dispersion into aqueous medium. Methods Based on the pre - optimized prescription of crataegi folium flavonoids SEDDS(Tween 80 - Transcutol P - ethyl oleate = 47:40:13), two more long chain lipid Labrafil M 1944 and Castor oil,and three medium chain lipid Labrafac CC,Capryol 90 and n -Capr - ylic acid were studied. The supersaturation SEDDS of long chain and medium chain lipid were evaluated for drug re-lease and droplets size in simulated gastrointestinal dissolution environment. Results The droplets size of medium chain lipid SEDDS significantly increased after loading with crataegi folium flavonoids,and it was obviously affected by the disso-lution medium. However,the long chain lipid SEDDS showed stable after loading with drug as well as in different dissolution media. The in vitro dissolution test showed that the long chain lipids SEDDS effectively sustained a supersaturated state by retarding precipitation kinetics,whereas medium chain lipids SEDDS showed precipitation within 30 min. Conclusion Compared with the medium chain lipid,the long chain lipid has a stronger ability to inhibit the precipitation.
Keywords：Crataegi folium flavonoidsSelf - emulsifying drug delivery systemSupersaturationLipid chain length
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 253-256 )