Electrospinning process and performance study of poly(D,L-lactic acid)absorbable barrier membranes
ZHU Aichen
MA Lixia
LI Wenming
SHI Jianhua
ZHU Xiaojie
ZHAO Jin
ZHANG Xianke
LIU Yang
SHI Rui
Abstract：To explore the potential application of poly(D,L-lactic acid)(PDLLA)in tissue repair,we used PDLLA as the sub-strate material and prepared the precursor solution by mixing chloroform and N,N-dimethylformamide(CF/DMF)as the solvent.PDL-LA absorbable barrier membranes were fabricated via the electrospinning process.The membrane exhibited a most probable pore size of 1.08 μm and porosity of 64.6%,which could provide appropriate channels for the transport of nutrients and excretion of metabolites.Mechanical test results showed that the membrane had a tensile strength of up to 7.09 MPa,elongation at break of 129%,and tearing force of 4.39 N,which could meet the mechanical requirements for tissue barrier membranes.In vitro degradation experiments con-firmed that the PDLLA membrane could maintain stable mechanical properties within a 3-month degradation period,ensuring the sus-tained and effective performance of the tissue isolation function.This study can provide a basis for the clinical application of PDLLA ab-sorbable isolation membranes.
Keywords：Poly(DL-lactic acid)ElectrospinningNano-fibersMicro-morphologyMechanical properties
Publication Date：2026-06-30
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：7( 227-233 )