Research progress on the role of miRNA in the diagnosis and treatment of Parkinson's disease
LIU Xiong
GONG Jiahuan
ZHANG Qi
Abstract：Parkinson's disease(PD)is a complex neurodegenerative disorder.The lack sufficient specificity of available clinical indicators for early diagnosis,and the limited pharmacological treatment options,creating a pressing need for reliable biomarkers for early diagnosis and specific therapeutic targets.Studies have revealed significantly different microribonucleic acid(miRNA)expression profiles in the bodily fluids of PD patients compared to healthy individuals,suggesting their potential diagnostic value in distinguishing PD.MiRNA participats in the pathogenesis of PD by regulating genes involved in oxidative stress,neuroinflammation,mitochondrial homeostasis and apoptosis and shows promise as diagnostic markers and therapeutic targets for PD.This review summarizes recent ad-vances in the use of miRNA for the early diagnosis and treatment in PD.By discussing the mechanisms of action and reviewing strate-gies for brain delivery,we aim to offer new perspectives for the clinical diagnosis and treatment of PD.
Keywords：Parkinson's diseaseMicroRNAMitochondriaOxidative stressEnergy metabolismDiagnosis and treatment
Publication Date：2026-04-30
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：7( 175-181 )