Numerical simulation study on airway stenosis based on the pressure feedback system
MA Chen
MENG Jiahuan
NI Zhong
WAN Huajing
CHEN Yu
LUO Fengming
Abstract：Addressing the critical limitation of traditional computational fluid dynamics(CFD)simulations in evaluating airway ste-nosis—specifically,the neglect of the alveolar pressure feedback mechanism.We developed a multi-scale numerical model based on dynamic alveolar pressure feedback.Utilizing a 0D-3D coupling strategy,the model integrated three-dimensional upper airway geome-try with lumped parameter models representing the peripheral lung units,successfully replicating the physiological feedback inherent in spontaneous breathing.The simulation results accurately captured core pathophysiological phenomena,including"pendelluft"(22.2 mL reflux per cycle)and the dynamic accumulation of intrinsic positive end-expiratory pressure(PEEPi,steady-state value:6.97 Pa),alongside a marked reduction in breathing efficiency.Furthermore,we mechanistically revealed that pressure imbalance,driven by regional heterogeneity in time constants,was the key factor deteriorating respiratory function.This research provides an innovative numerical simulation framework for the functional assessment of airway stenosis and personalized treatment planning.
Keywords：Airway stenosisNumerical simulationPressure feedback systemMulti-scale couplingComputational fluid dy-namic
Publication Date：2026-04-30
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：6( 127-132 )