Electrophysiological coupling study of lumbar dorsal root neurons treated with pulsed radiofrequency
CUI Haokun
NAN Qun
Abstract：To explore the physiological mechanism of the electrophysiological model of pulsed radiofrequency(PRF)and neuronal coupling in pain treatment,based on the Hodgkin-Huxley(HH)model,the electrophysiological models of healthy and pathological states(Na1.7 and Na1.8 channel conductance increased by 125%and 115%,respectively,and K channel conductance decreased by 85%)were constructed.At the same time,time-varying electric field stimulation combined with PRF(frequency 2 Hz,pulse width 20 ms,voltage 45 V and time 120 s)were coupled.The results showed that before treatment,the pathological model discharged 6 times every 500 ms without stimulation,and the discharge was persistent and irregular.When the stimulus was increased to 0.02 and 0.05 μA/cm2,discharges of 15 and 28 times per 500 ms occured,respectively,and the firing frequency increased with the increase of stimu-lus intensity.After treatment,there was no spontaneous discharge when no stimulation,and the resting membrane potential was-65 mV.However,when the external stimulation current density was 0.02 μA/cm2,discharges of 10 times per 500 ms were all close to the healthy model.This study can provide a key theoretical tool for the optimization of PRF treatment parameters and the study of pain treatment regimens.
Keywords：Pulsed radiofrequencyLumbar dorsal root neuronsElectrophysiologyHodgkin-Huxley modelmembrane potential
Publication Date：2026-04-30
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：8( 119-126 )