Preparation and properties of the modified gelatin nasal hemostatic sponge
LI Hongmei
QU Changfeng
LI Bo
ZHENG Xuanjie
ZHAO Lei
HOU Xiuju
HAN Aimin
ZHANG Xianke
Abstract：In order to improve the antibacterial and hemostatic properties of gelatin nasal hemostatic sponge,we cross-linked and modified gelatin using squid chitosan,then compounded it with polyvinyl alcohol,and finally prepared the modified gelatin nasal hemo-static sponge through freeze-drying.The effect of the hemostatic sponge was explored through tests on its physical and chemical proper-ties,antibacterial properties,hemostatic performance and cytotoxicity.The results showed that the breaking force of the modified gelatin nasal hemostatic sponge was 14.78 N,the expansibility was 3.27 times,the water absorption ratio was 36.5 times,and the average an-tibacterial rates against Staphylococcus aureus and Escherichia coli reached 100%and 98.80%,respectively.The cell survival rate ex-ceeds 90%and the effective hemostasis time is 14 s.The modified gelatin nasal hemostatic sponge prepared exhibits rapid hemostasis,good antibacterial performance,no cytotoxicity and broad clinical application value.
Keywords：GelatinModificationSquid chitosanExpandBacteriostasis
Publication Date：2025-08-30
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：6( 264-269 )