A method for preparing polyvinyl alcohol microspheres with controllable particle size based on liquid jet breakup
ZHAO Pei
XU Ke
WU Di
HUANG Linjing
YANG Zhiqiang
ZOU Fangming
ZHAO Chengru
XIA Yiran
Abstract：In the industrial production,polyvinyl alcohol(PVA)microspheres are mostly prepared by mechanical stirring method,resulting in uncontrollable particle size,wide particle size distribution and low yield of small particle size(100～300 μm)micro-spheres.To improve these issues,PVA hydrogel microspheres with controlled particle size was prepared by liquid jet breakup method.The processing conditions,dispersed phase flow rate,PVA concentration,diameter of the feeding device and the stabilizer concentra-tion were optimized to fabricate PVA microspheres.Finally,the PVA microspheres with an average particle size of 146.00 μm and size distribution coefficient of 1.63 were successfully fabricated by using 400 μm feeding device under the dispersed phase flow rate of 40 mL/min,the dispersed phase concentration of 7.0%,and the stabilizer concentration of 11.5%.This method improves the yield of small particle size microspheres,has good repeatability between batches,which can realize large-scale production of microspheres.
Keywords：Interventional embolizationLiquid jet breakuppolyvinyl alcohol microspheresFeeding deviceParticle size distribution
Publication Date：2024-04-28
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：7( 159-165 )