Research on non-invasive detection technology of hemoglobin concentration based on multi-wavelength near-infrared spectroscopy
PENG Fulai
CHEN Cai
ZHANG Ningling
WANG Xingwei
LÜ Danyang
WANG Weidong
Abstract：Aim at the problem that traditional hemoglobin concentration detection requires blood sampling,the detection process is complicated and cannot continuously monitor the variation trend of human hemoglobin concentration,we proposed a non-invasive hemo-globin detection method based on multi-wavelength near-infrared spectroscopy.Firstly,a mathematical model for non-invasive hemo-globin detection was established based on the Beer-Lambert law,and an eight-wavelength near-infrared PPG signal acquisition system was designed based on this model.Then,the collected PPG signals were pre-processed to reduce noise and baseline drift,and the fea-ture information was extracted and selected according to the established non-invasive detection model.Finally,the hemoglobin predic-tion regression model was constructed based on the Stacking algorithm.249 clinical data were used to verify the performance,the root-mean-square error between the predicted value of the non-invasive detection model and the reference value was 1.17 g/dL,and the cor-relation coefficient was 0.75.The experimental results show that this method can achieve non-invasive detection of hemoglobin concentra-tion effectively.
Keywords：Hemoglobin concentrationNon-invasive detectionPhotoplethysmography signal processingStacking regression
Publication Date：2024-02-28
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：6( 70-75 )