Numerical simulation analysis of the effect of inhalation-pressure interval on the asthma drug particle deposition
YAN Sixin
FENG Sen
CUI Biao
ZHANG Zhiguo
Abstract：In order to analyze the effect of inspiration-press interval on the deposition of drug particles in vivo,the numerical simu-lation was used to analyze the distribution of drug particles in vivo deposition in asthma patients when using metered-dose inhalers.Firstly,the 3D numerical model of human respiratory tract was reconstructed from CT data obtained in clinic.Then,the geometric mod-el of asthma metered-dose inhaler was established and combined with the previous respiratory model.Finally,the computational fluid dynamics method was used to simulate the in vivo transport of asthma drug particles.The results showed that with the Δt shortened,the deposition rate of drug particles in the oropharynx gradually decreased,while the deposition rate of particles in the lower airway gradual-ly increased.When Δt=0 s,the deposition fraction of particles in the oropharynx decreased to the lowest value of 49.87%,and the cor-responding particles entering the lower airway reached the highest value of 35.04%.It can provide important theoretical guidance for in-telligent assisted drug delivery technology in the future,so as to improve the efficiency of drug delivery.
Keywords：AsthmaMetered-dose inhalerComputational fluid dynamicsInspiration-press intervalDeposition rate
Publication Date：2023-12-25
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：6( 362-367 )