Evaluation of tissue mechanical properties based on magnetomotive optical coherence elastography
XIAO Ting
RONG Ziqi
QIN Xi
ZHANG Xinyu
Abstract：The magnetomotive optical coherence elastography(MM-OCE)can detect the tiny vibrations of the tissue loaded with magnetic particles,analyze the vibration information,and extract the parameters that can reflect the biomechanical properties of the tis-sue.We used the solenoid magnetic excitation and optical coherence tomography acquisition to establish the MM-OCE research plat-form,which records the vibration response of the tissue loaded with magnetic nanoparticles under the excitation of the sweep signal to determine the mechanical resonance frequency of the tissue,so as to characterize the biomechanical properties of the tissue semi-quan-titatively.The results showed that the resonant frequency increased when the portion of gelatin was enhanced in the gelatin phantom,in-dicating the increase in stiffness for the gelatin phantoms.After cross-linking treatment with glutaraldehyde collagen on the ex vivo cor-nea,the resonance frequency of ex vivo corneas increased with the increase of glutaraldehyde concentration,indicating that the reso-nance frequency could reflect the difference of corneal hardness.This research can evaluate the difference of mechanical properties of tissues and has great potential for clinical application.
Keywords：Biomedical measurementElastographyOptical coherence tomographyMagnetomotive imagingMagnetic nanoparti-clesBiomechanics
Publication Date：2023-12-25
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：6( 344-349 )