Determination of Residual P-dioxanone in Biodegradable Poly( P-dioxanone)
ZHU Aichen
MA Lixia
YANG Qinghua
LIU Yang
WANG Chuandong
LI Junqi
Abstract：A gas chromatography method was established for determination of residual P -dioxanone in poly ( P-dioxanone ) .DB-624 capillary column (30.0 m ×535μm ×3.00μm) was used, the oven temperature was initially held at 146℃for 5 min and then programmed to 200 ℃at 30 ℃/min and held for another 2 min.The carrier gas was nitrogen , the injection port temperature was 240℃, and the temperature of FID was set at 250℃.The split ratio was 5:1 and the sample volume was set at 2μL.The results showed that the concentration of P -dioxanone was good linear in the range of 0.0239~0.1794 mg/mL.The recovery of P -dioxanone was 100.3 %, and the relative standard deviation was 1.39 %.The limit of detection was 0.0002 mg/mL, and the limit of quantification was 0.0005 mg/mL.The method is simple, rapid, accurate and sensitive.
Keywords：Poly(P-dioxanone)P-dioxanoneResidual monomerGas chromatography (GC)Biodegradation
Publication Date：2017-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：4( 366-369 )