The Effect of Heparin-and Chondroitin Sulfate-based Nanoparticles Modified Surface on Biocompatibility
CAO Jianjun
LIU Tao
WANG Guodong
TANG Xiaohan
PANG Liqun
PAN Changjiang
Abstract：Heparin-and Chondroitin sulfate -based nanoparticles were synthesized in this study for biofunctional modification of 316L SS surface.The physical and chemical properties of NPs and NPs modified surface were characterized with laser particle size a -nalysis, FTIR, AFM and water contact angle assay .In vitro blood compatibility and cellular compatibility were carried out to investi-gate the influence of two kinds of NPs on surface biocompatibility .According to the result , two kinds of NPs were found to effectively prevent platelet adhesion and aggregation .The heparin-based nanoparticle modified surface , however , may inhibit the proliferation ac-tivity of endothelial cells (ECs), while the chondroitin sulfate-based nanoparticles is found to stimulate ECs adhesion and proliferation .
Keywords：DopamineChondroitin SulfateHeparinNanoparticlesCoagulationEndothelialization
Publication Date：2017-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：6( 361-365,391 )