Electric Properties Measurements of Biological Tissues Using A Microprobe

CAO Shuang; ZHANG Yan; MA Ren; ZHANG Shunqi; YIN Tao; LIU Zhipeng

doi:10.19529/j.cnki.1672-6278.2017.04.01

Abstract：Electrical properties ( EPs;conductivity&permittivity ) as an eigenvalue can be used to distinguish the biological tissues ( for example:normal tissues vs .tumor tissues ) and then diagnosis early disease , particularly tumor disease .EPs of biological tissues have close connection to its physiological and pathological conditions .As the EPs of biological tissues changes obviously after excised , the in-vivo data of biological tissue EPs is more accurate and is of great importance for diagnosis .This study developed a small size insertion-type probe to measure EPs of cancer ( MDA MB 231 ) , which was cultivated and implanted into the mammary fat pad of BLAC/c nude mice .The measurements was also performed on the normal tissues and the ex -vivo tissues .Frequency of measurements range was from 0.5 to 5 MHz.After measurements, pathological examinations on the measure tissues were conducted .There were sta-tistically-significant differences between malignant breast tissue and normal tissues for the conductivity and permittivity (P<0.01);there were also statistically -significant differences between in -vivo data and ex -vivo data(P<0.01).And the measure results showed the changes of EPs as the breast cancer developing .The results indicate that measurements of biological tissues using the newly developed small size probe have significant difference between in -vivo EPs and ex-vivo EPs.And measuring EPs of biological tissues in-vivo has great importance for cancer early diagnose by the EPs changes.