Determination of Residual DL-Lactide,Glycolidc and 1,3-Trimethylene Carbonate in DL-Lactide-Glycolide-Trimethylene Carbonate Terpolymers
MA Lixia
ZHU Aichen
DONG Hao
LIU Yang
WANG Xianpeng
WANG Qin
WANG Chuandong
Abstract：To establish a method of determination of residual DL-lactide (DL-LA), glycolide (GA) and 1,3-trimethylene carbonate (TMC) in DL-lactide-glycolide-trimethylene carbonate terpolymers (PLGA-TMC) by gas chromatography.GsBP-5 capillary column (30 m×0.32 mm, 0.25 μm), and FID detecter were used.The inlet temperature was set 250℃, the temperature of FID was 300℃, the column temperature was kept at 135℃, and the split ratio was 10:1.The results showed that DL-LA, GA and TMC were well separated, the relative standard deviations (RSDs) were all less than 2.0%, each monomer had a good linear relationship in the appropriate concentration range, and the correlation coefficient was not less than 0.999, the average recoveries were 97.17%~101.71%, and the RSDs were less than 5.0%.The method has good specificity and high accuracy, and can be used in the determination of residual monomers and the quality control of PLGA-TMC.
Keywords：LactideGlycolideTrimethylene carbonateMonomer residualGas chromatography
Publication Date：2017-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：4( 268-270,276 )