Preparation and Quality Evaluation of Thermosensitive Vaginal Acid Buffer in-situ Gel
Abstract：To prepare a thermosensitive gel,which is liquid in room temperature and undergoes a phase transition to bioadhesive gel at body temperature.The transition is rapid that make it is easy to spread out and attatch to vaginal wall and cervix uterus,and help the vaginal wall and cervix uterus make contact with the gel.The existence of acid buffer system can maintain pH between 3.5 to 4.5 in vaginal wall,thus acid ambient can be recoverd.The in-situ vaginal gels administered intravaginally had no significant systemic and local toxicity.And it is not irritative to vaginal in rabit.This product has no sensitization to skin.The gel has bacteriostasis and spermatocidal effects.
Keywords：in-situ gelsacid buffer systemvaginal retentionvaginal irritationbacteriostasis
Publication Date：2017-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：4( 164-167 )