The Effect of Acute Alcohol Consumption on the Spikes of Hippocampal CA1 Area
YU Hejuan
ZHANG Yameng
ZHANG Yan
QIAN Zhiyu
TAO Ling
LI Weitao
Abstract：To study the characteristics and evaluate the effects of acute alcohol consumption on memory function,weobserved the discharge frequency and interspike interval (ISI)changes of spike potentials from the hippocampal region of the mice.ICR mice were divided into 2 groups (n =8),including acute alcohol consumption group (P group)and saline control group (C group).The 8 -channel microelectrode arrays were implanted in the CA1 region of the hippocampus of mice and then the signals before and after acute alcohol drinking were recorded by Cerebus,a signal processing system.At last,the changes of discharge frequency and Interval Histo-grams Interspike (ISI)of the hippocampal neurons were investigated.The mean values of firing rate were lower in control group than those in alcohol consumption group.In the alcohol consumption group,firing rate began to decrease right after the injection.After 20 min,the firing rate began to increase gradually.With the time from pre -injection to 80 min post injection,the ISI values became more dispersed.There are obvious differences in the characteristics of the discharge frequency and ISI in the hippocampus of mice.A-cute alcohol consumption can inhibit the neuron discharge in hippocampus and the memory function of mice.
Keywords：Hippocampal areaSpike potentialAcute alcohol consumptionDischarge frequencyInterspike intervalCharacter-istic differenceMemory function
Publication Date：2016-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：5( 183-187 )