The Effect of Astrocytes in the Brainstem on the Stress -induced Gastric Mucosal Injury in Rats
QIN Xue
LIU Zhen
WANG Jing
TONG Lingyin
SUN Haiji
Abstract：To investigate the effect of astrocytes in the nucleus of solitary tract (NTS)and dorsal motor nucleus of the vagus (DMV)on the stress -induced gastric mucosal injury in rats.Thirty -six male Wistar rats were randomly divided into the control group and the Restraint water -immersion stress(RWIS)(0.5、1、2、3、5h)groups.Glial fibers acidic protein (GFAP)expression were tested by immunohistochemical staining.Twelve male Wistar rats were randomly divided into the saline control group and L -AA (inhibition of astrocytes)group.1 h after RWIS,the Fos and the GFAP expression and the damage of gastric mucosa were detected. Results showed that compared with the control group,the number of GFAP positive astrocytes in DMV and NTS in the RWIS groups was significantly increased.The GFAP expression peaked at 1 h after the stress and the spatial of GFAP expression were different.L -AA significantly inhibited GFAP and Fos positive expression in the brainstem (NTS and DMV)and reduced gastric mucosal injury. Astrocytes may participate in the gastrointestinal dysfunction and the gastric mucosal damage induced by RWIS through regulating the activation of neurons.
Keywords：StressAstrocytesFosNucleus of solitary tractDorsal motor nucleus of the vagus
Publication Date：2016-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：7( 168-174 )