Numerical Simulation of the Effect of Smooth Muscle Layer on the Stress Distribution in the Airway Wall
SHI Xiaohao
CHEN Jian
ZHOU Shengye
DENG Linhong
Abstract：Many chronic respiratory diseases are associated with airway remodeling.It is well known hyperplasia and hypertrophy of smooth muscle directly affect the mechanical properties of the airway.This can cause uneven distribution of stress in the airway,leading to local stress stimulation increase in the inner layer.In present work,we built a finite element model which simplified the anatomical structure of airway into a three -layers structure:inner wall,smooth muscle layer and the adventitia layer.This model was further used to analyze the mechanical properties variation of airway smooth muscle layer under physiological and pathological situations.It was ob-served that the minimum stress occurr in the adventitia layer.While smooth muscle layer thickening and local smooth muscle hyperplasia can lead to the stress increase of airway smooth muscle layer.With the same hyperplasia area,the stress of the smooth muscle layer in-crease along with the increasing numbers of hyperplasia.In addition,the distribution of hyperplasia in smooth muscle layer has a great in-fluence on airway mechanical properties,the more concentrated the hyperplasia is,the greater the stress value of airway ever receive.
Keywords：AirwayAirway smooth muscleHyperplasiaStressNumerical simulation
Publication Date：2016-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：5( 157-161 )