Synthesis and Characterization of a New Thermosensitive Polymer in Situ Gelation as Medical Liquid Embolic Material
ZHU Xiaojie
ZHU Xiaomin
MENG Jianwen
LUO Xiyou
LI Hongmei
ZHANG Suwen
WANG Chuandong
FENG Shengyu
Abstract：Thermosensitive copolymers poly(NIP -co -BMA)of N -isopropylacrylamide (NIP)with Butyl Methacrylate (BMA) in situ gelation were synthesized by free radical copolymerization.FTIR results confirmed the structure of the monomer NIP and copoly-mer poly(NIP -co -BMA).The intrinsic viscosity and the lower critical solution temperature (LCST)of copolymer was investigated. The results indicated that the LCST was decreased with the higher concentration of BMA.The phase transition of the copolymers solu-tion occurred at body temperature and the copolymers changed the soft solids.The copolymers has a promise application in medical liq-uid embolic materials for arterial aneurysm.
Keywords：In situ gelationThermosensitive copolymerNonadhesive liquid embolic materialsN -isopropylacrylamideButyl Methacrylate
Publication Date：2015-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：5( 110-114 )