Fabrication and Biocompatibility Investigation of a Novel Hemostatic Material
WANG Yanling
LIU Guangwan
WU Lijuan
QU Hongyuan
ZHAO Fang
YANG Guang
WU Changlin
Abstract：The novel hemostatic material was fabricated from starch,hyaluronic acid and STMP with freeze -drying technique. The microstructure,crystalline structure and thermal stability of the material were studied by SEM,XRD and DSC respectively.And the biocompatibility of this material was investigated by subcutaneous reactivity,sensitization,acute systemic toxicity and cytotoxicity tests described in GB/T16886.The results showed that the crosslinking reaction occurred in amorphous area and this novel hemostatic material presented three -dimensional network structure which was of favourable thermal stability.Animal experiments indicated that the material had no subcutaneous reactivity,no sensitization,no acute systemic reaction and no cytotoxicity.It is concluded that this novel hemostatic material shows promise for clinical applications.
Keywords：Starch -hyaluronic acidFreeze -dryingCross -linkingHemostaticBiocompatibility
Publication Date：2015-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：4( 102-105 )