Study of Tumor with Frontal Lobe by the Fractional Amplitude of Low Frequency Fluctuation of Resting-state Functional Magnetic Resonance Imaging
ZHAO Cuihua
TAO Ling
YU Zhou
WU Jiangfen
SUN Jinyang
ZHOU Hui
Abstract：To investigate pathological mechanism of dysfunction of cognitive control in tumor in frontal lobe,using a resting-state functional magnetic resonance imaging (fMRI)index,fractional amplitude of low frequency fluctuation (fALFF).14 patients with tumor in frontal lobe and 14 gender,age and education-matched healthy controls were experienced resting-state fMRI scans.fALFF approach was used to analyze fMRI data in resting state.Compared with healthy control group,the group with frontal lobe tumor showed the increased value of fALFF in the right orbitofrontal,right temporal lobe,right supplementary motor area,left parahippocampal gyrus, left posterior cingulate gyrus,the left medial cingulate and paracentral lobule,in the bilateral dorsolateral frontal gyrus,bilateral medial frontal gyrus and Cerebelum.The results show the decreased functional activity in the frontal area of the resting state in the patient′s tumor in frontal lobe ,which is part of the frontal lobe tissue of the inactivation of tumor,whereas the rest of the default mode network re-gions and the enhancements of supplementary motor area may be related to cognitive dysfunction and compensatory effect.
Keywords：Resting-stateFunctional magnetic resonance imaging (fMRI)Fractional amplitude of low frequency fluctuation (fALFF)Frontal tumorDefault mode network (DMN)
Publication Date：2015-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：5( 11-14,22 )