Cellular-level Studies of Effect of Skin Anti-wrinkle Formulas Containing SHAC
LIU Shaoying
LIU Xia
YANG Suzhen
CHEN Jianying
LIU Fei
ZHU Xiqiang
LING Peixue
Abstract：Silanol hyaluronate compound (SHAC)is a kind of hyaluronic acid derivatives.Humanoid collagen and carnosine are mainstream products on the prevailing skin anti-wrinkle market.In this study,SHAC was used in skin anti-wrinkle formulas to study the effect on fibroblasts.SHAC was mixed with humanoid collagen and carnosine,respectively.These two mixtures were added to the cultured L929 cells,respectively.To evaluate the protective effect of SHAC against UVB-irradiation,we detected cell viability by MTT assay in L929 cells,which are treated with humanoid collagen,carnosine singly,and in combination with SHAC.Results showed that:(1 )Carnosine could significantly attenuate the decreased cell viability induced by UVB-irradiation in L929 cells.The effect of humanoid collagen was not obvious in these experimental treatments.(2 )Comparing to cells treated with humanoid collagen and carnosine singly,formulations containing SHAC could elevate the cell viability significantly and inhibited the UVB-induced L929 cells damage.SHAC can enhance the effect of humanoid collagen,carnosine and can be used in skin anti-wrinkle products.
Keywords：Silanol hyaluronate compound (SHAC)Human-like collagenCarnosineFormulationProliferative activityUltravi-olet damageSkin anti-wrinkle
Publication Date：2014-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：4( 251-254 )