The Subchronic Systemic Toxicity Research on the Medical Chitosan in Rats
LIN Xiaodong
CHENG Yanling
LIU Na
YING Yong
HU Jianting
Abstract：As a new type of medical polymer materials,the biological safety of medical chitosan was evaluated through subchronic systemic toxicity study.Forty SD rats were randomly divided into control group and test group,and injected by intraperitioneal route,2 times a week,for 13 weeks.Body weight and feed intake were measured weekly and clinical observations were performed daily through-out the trial.Hematology,blood biochemistry and the histopathology of 30 organs and tissues were investigated at the end of the trial. There were no animal death during the experiment,no obvious changes in clinical observations,feed intake,organ weight,hematology, blood biochemistry or histopathology between test group and control group.The rats′weight of the test group were lower than that of the control group for a short time after injection.The biological test results were in the acceptable range.The medical chitosan does not in-duce subchronic toxicity,and has good biological safety.
Keywords：ChitosanChitinPoly-acetylglucosamineMedical deviceSubchronic toxicitySystemic toxicity studiesBiological e-valuationBiosecurity
Publication Date：2014-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：4( 113-116 )