Numerical Study on the Effects of Drug Release Profile of Two Drug -eluting Stents on the Drug Concentration within the Vessel Wall
WU Hao
JIANG Wentao
YAN Fei
CHEN Yu
FAN Yubo
Abstract：To study the effects of two drug release profiles on the drug concentration for better design of drug -eluting stents (DES).A 3D virtual drug -eluting -vessel stent was modeled,and numerical simulation was used to investigate the drug concentration within the vessel wall at the drug release profile of rapamycin and paclitaxel,The initial drug concentration was increased with initial drug release rate increasing,but over time the drug concentration in the vessel wall would be stabilized.The drug concentrations pro-duced by both drug release profiles were first increased and then decreased with time,and compared with the concentration variation trend of paclitaxel,the concentration variation trend of rapamycin was steadier.In addition,the rapamycin concentration distribution in the vessel wall was more uniform than the paclitaxel concentration distribution.The stability of the drug concentration variation trend and the uniformity of drug concentration within the vessel wall show that rapamycin release profile is better than paclitaxel release profile.
Keywords：Drug -eluting stents(DES)Drug release profileDrug concentrationRapamycinPaclitaxel
Publication Date：2013-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：6( 206-211 )