The Effect of Tangmaitong on mRNA Expression of VEGF in the Vascular of Diabetic-hyperlipidemia Rats Model
CAI Xinrui
LI Zhiying
QIAN Weibin
QIAN Qiuhai
Abstract：To study the effect of Tangmaitong,which was based mainly on invigorating the qi,promoting blood,removing toxicity and dredging collateral on mRNA expression of VEGF in the vascular of diabetic-hyperlipidemia rats′model.Rats′model were made with STZ and high-quality diet.Then the rats were divided into four groups.After 12 weeks of drug intervention,rats were killed,the vascular were removed and the mRNA expression of VEGF in the vascular was observed by the method of RT -PCR.The mRNA expression of VEGF was significantly increased,and Tangmaitong could lower the mRNA expression of VEGF in the vascular of diabetic-hyperlipidemia rats′model in a dose -dependent manner.The abnormal expression of VEGF can be one of the mechanisms for diabetic vascular disease.The treatment method of invigorating the qi,promoting blood,removing toxicity and dredging collateral in early stages has an obvious effect.Tangmaitong has a good protective effect on the vascular by an adjustment effect on the expression of VEGF,and deserves further research.
Keywords：TangmaitongDiabetic vascular diseaseVascularendothelial growth factor(VEGF)RT-PCRAnimal experiment
Publication Date：2013-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：4( 189-191,200 )