Effects of Calcium Signaling Early Intervention on the Expression of Calmodulin-dependent Protein Kinase II and Apoptotic in Hypertrophied Cardiomyocytes in Rats
LUO Ji
LI Yan
Abstract：To establish the animal′s models of hypertrophied cardiomypcytes,to investigate the effect of L-type calcium channel blockers on the expression of calmodulin-dependent protein kinase II(CaMKII),the Ca2+-ATPase,ATP,ASK1,cell viability and apoptotic in myocardial cells.,in order to understand calcium antagonists in the process of myocardial hypertrophy role thoroughly.It can significantly improve CaMKII signal system activity,and keep the myocardial intracellular calcium homeostasis,inhibiting myocardial apoptosis by the early application of calcium antagonists.
Keywords：Hypertrophied cardiomypcytesCaMKIIL-type calcium channel blockerCalciumApoptotic cells
Publication Date：2013-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：5( 184-188 )