The Shear Mechanical Characteristic Comparative Analysis of the Animal Model of Osteoporosis Bone Interfered with Several Drugs
WANG Yafen
LUO Min
TONG Wenxia
Abstract：To conduct the testing of shear mechanical properties on the tibial rats between the normal control group,the osteoporosis model group with Dan Qi particles,ipriflavone,combined type,estrogen Premarin,and the αD3 treatment,and to determine the various osteoporosis therapy effect.The rats′left,right tibia were gotten to do shear experiment after feeding15 weeks,The senile osteoporosis animal model was made by the method to remove the ovaries,and the Dan Qi particles,ipriflavone,conjugated estrogen (Premarin tablets),αD3 treatment were used.The results showed that the maximum load,maximum,the shear stress of osteoporosis animal model group were significantly lower than those in normal control group and the treatment group (P<0.05 ),maximum strain and αD3 group showed no significant difference (P>0.05 ).Treatment of rats with Dan Qi particles,the maximum load,maximum shear stress,maximum shear strain and the rats′tibial maximum load,maximum shear stress,maximum shear strain of normal control group showed no significant difference (P>0.05 ).The shearing properties of the model group rats′tibial had changed because the osteoporosis.The shear mechanical properties of Dan Qiparticles,ipriflavone,combined type,estrogen premarin treatment group are improved,the best one is Dan Qi particles,and there is no significant increasing in tensile mechanical properties with the αD3 group.
Keywords：AgingOsteoporosisAnimal modelDrug treatmentShearMechanical properties
Publication Date：2013-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：3( 171-173 )