RELATIONSHIP BETWEEN DEGRADATION OF β- TCP AND OSTEOGENESIS INDUCED BY rhBMP-2
Wang Dan
Hu Yunyu
Zheng Changqiong
Zhao Guangyue
Xie Kenan
Lu Rong
Wang Jun
Abstract：To determine if degradation rate of β - TCP may influence the amounts of bone formation induced by rhBMP- 2.Two kinds of β- TCP/rhBMP- 2 composites(β- TCP1/rhBMP- 2and β- TCP2/rhBMP- 2) which own different degradation rate, were fabricated by combining β - TCP1and β - TCP2 with rhBMP - 2, and implanted into the muscle pouches in the thigh of mice.Histological study, histomorphometry, assay of alkaline phosphatase and degradation amounts of two kinds of β - TCP/rhBMP - 2 were performed after implantation.Both of β - TCP1/rh BMP - 2 and β - TCP2/rhBMP - 2 composite implants showed signs of cartilage and bone formation. The amounts of new bone were increasing with time.But the amounts of new bone in β - TCP1/rhBMP - 2 implants were much greater than in β-TCP2/rhBMP-2 implants at 8- week after implantation(P＜ 0.05). The levels of ALP activity in both groups were increasing with time before 4 weeks postimplantation (P ＜ 0.05), but there was no change during 4～8 weeks. Besides, biodegradation rate of β- TCP1/rhBMP - 2 was higher than that of β - TCP2/rhBMP - 2 at 8 - week after implantation(P＜0.05).The degradation rate of β - TCP can influence the amounts of BMP - inducing bone formation.
Keywords：Calcium phosphates Degradation Osteogenesis
Publication Date：2001-01-01
Online Publishing Date：2026-09-11(First online date of this platform, not the publication date of the document)
Pages：9( 1-9 )