Meta analysis of high risk factors of VAP in neonates
Abstract：Objective:To systematically analyze the high risk factors of ventilator - associated pneumonia(VAP)in neonates in order to provide the basis for the scientific development of the early warning and prevention strategy of VAP. Methods:We retrieved all studies about the ventilation - related factors of VAP in neonates in CNKI,Wanfang,CBM,ISI,Pubmed and Embase and evaluated their risk of bias by Newcastle - Ottawa scale and analyzed all data by qualitative and meta - analysis. Results:20 cases were included in the control study,in-volving 3497 neonates in NICU(1173 cases of VAP)and 3 types of mechanical ventilation related factors. The results of meta - analysis showed that significant differences were found in reintubation,average intubation times,repeated suctioning,suctioning≥8times/ d,average ventilator time,the duration of ventilation ﹥ 7d,ventilation≥4d and ventilation ﹤ 4d(P ﹤ 0. 01). Conclusion:This study confirms that the reintubation and repeated suctioning can increase the risk of VAP and they are the important risk factors and early warning index. Further research is needed to reveal the dynamic relationship between sputum suction times or ventilation time and the VAP risk.
Keywords：NeonateVAPMechanical ventilationHigh risk factors
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 10-15 )