A healthy lifestyle pattern and mortality risk in patients with type 2 diabetes mellitus:A prospective cohort study in China
Hao Yu
Xinyi Liu
Xueni Cheng
Xikang Fan
Yuefan Shen
Ke Liu
Yanan Wan
Jian Su
Yu Qin
Zhongming Sun
Yan Lu
Shujun Gu
Chong Shen
Dong Hang
Jinyi Zhou
Abstract：This study aimed to evaluate the association of a healthy lifestyle pattern with mortality risk among patients with type 2 diabetes mellitus (T2DM). Data were derived from a prospective cohort study enrolling 13,776 Chinese patients with T2DM. A healthy lifestyle pattern was constructed based on six lifestyle factors, including smoking status, alcohol consumption, dietary habits, physical activity, sedentary time, and sleep duration. Multivariate Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortality. During a median follow-up of 9.78 years, 2,497 deaths were recorded. Compared with T2DM patients with a lifestyle pattern scoring 0-2, those scoring 5-6 had a 40% lower risk for all-cause mortality (HR=0.60, 95% CI: 0.52-0.69), a 33% lower risk for cardiovascular disease mortality (HR=0.67, 95% CI: 0.52-0.86), and a 25% lower risk for cancer mortality (HR=0.75, 95% CI: 0.58-0.97). Additionally, we found that the association between the lifestyle pattern and all-cause mortality risk was stronger in females than in males (P for interaction < 0.05). In conclusion, adherence to a healthy lifestyle pattern is associated with a decreased risk of all-cause, cardiovascular disease, and cancer mortality. These findings have important implications for reducing premature mortality among patients with T2DM.
Keywords：healthy lifestylemortalitytype 2 diabetes mellitusprospective cohort study
Publication Date：2025-11-30
Online Publishing Date：2026-01-15(First online date of this platform, not the publication date of the document)
Pages：10( 639-647,中插29-中插35 )