Effect of Compound Danshen Dripping Pills on cardiac function after acute anterior ST-segment elevation myocardial infarction:A randomized trial
Bo Deng
Sibo Wang
Yujie Wu
Qiming Wang
Rui Qiao
Xiwen Zhang
Yuan Lu
Li Wang
Shunzhong Gu
Yuqing Zhang
Kaiqiao Li
Zongliang Yu
Lixing Wu
Shengbiao Zhao
Shuanglin Zhou
Yang Yang
Liansheng Wang
Abstract：The current study aimed to evaluate the efficacy and safety of Compound Danshen Dripping Pills (CDDP) in improving cardiac function in patients with acute anterior ST-segment elevation myocardial infarction (AAMI). Between February 2021 and February 2023, 247 eligible patients with AAMI after primary percutaneous coronary intervention were enrolled and randomly assigned (1∶1) to receive CDDP (n=126) or placebo (n=121), with a follow-up of 48 weeks. Compared with the placebo group, the CDDP group demonstrated a significant increase in left ventricular ejection fraction values after 24 weeks of treatment (least squares mean: 3.31; 95% confidence interval [CI]: 1.72-4.90; P＜0.001) and at the 48-week follow-up (least squares mean: 4.35; 95% CI: 2.76-5.94; P＜0.001). Significant reductions in N-terminal pro-B-type natriuretic peptide levels were observed in both groups at the 24- and 48-week visits with no significant difference between the two groups (P＞0.1 for all). The incidence of major adverse cardiovascular and cerebrovascular events was 6.35% in the CDDP group and 5.79% in the placebo group (P=0.822). Notably, no serious adverse events were attributed to CDDP. These findings suggest that CDDP may be well tolerated and could improve left ventricular ejection fraction in patients with AAMI at 24 and 48 weeks.
Keywords：Compound Danshen Dripping Pillscardiac functionacute anterior myocardial infarctionrandomized controlled trial
Publication Date：2025-07-30
Online Publishing Date：2025-10-11(First online date of this platform, not the publication date of the document)
Pages：10( 407-416 )