Genetic Variation in β3-Adrenergic Receptor and Obesity,Type 2 Diabetes,Insulin Resistance in Chinese Pedigrees
Abstract：Objective: To explore the association between the polymorphism of the β3-adrenergic receptor(R-AR) gene and obesity, type 2 diabetes, insulin resistance in Chinese pedigrees. Methods: Eight pedigrees with obesity and type 2 diabetes have been detected with the technique of PCR-RFLP in codon 64 of the exon region representing the variation Trp64 Arg of β3-AR gene. Results: In pedigree linkage analysis, the maximal LOD score of β3-AR gene with obesity was 3. 385 109 ( 0 = 0.000 000) at the mode of autosomal dominant in pedigree 3. The maximal LOD score of β3-AR with type 2 diabetes was 0.222336(0 =0. 000 000) at the mode of autosomal dominant in pedigree 2 and 0.805 003 ( 0 = 0.000 000) at the mode of autosomal recessive in pedigree 4.ial obesity. Pedigree linkage analysis can powerfully help to understand the action mechanism of the candidate genes. 2Better comphrehension the workings of adrenergic receptors should provide a new understanding of obesity, type 2 diabetes and insulin resistance and perhaps lead to new methods of treatment.
Keywords：β3-adrenergic receptorgeneobesitytype 2 diabetes mellitusinsulin resistancemolecular genetics
Publication Date：2004-08-31
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 250-255 )