Association between β2-adrenergic Receptor Genetic Polymorphisms and Nocturnal Asthmatic Patients of Chinese Han Nationality
Abstract：Objective: To analyze the association between β2-adrenergic receptor (β2-AR)genetic polymorphisms and nocturnal asthmatic patients of Chinese Han nationality. Methods: Polymerase chain reaction-allele specific oligonucleotide hybridization assay was used to determine 16 and 27 locus alleles of β2-AR genetic polymorphisms in 25 nocturnal asthmatic patients (NA group), 22 nonnocturnal asthmatic patients (NNA group)and 72 healthy people ( control group). All subjects were from Chinese Han nationality. Results: The distribution frequency of genotype Arg/Arg, Arg/Gly, and Gly/Gly at β2-AR 16 loci was 12%, 16% and 72% in NA group;and was 27 %, 41% and 32 % in NNA group. There was significant increase in the frequency of genotype Gly/Gly and allele Gly in NA group, compared with NNA group(P ＜0. 01 ). However, there was no significant difference in the frequency of genotype Gly/Gly and allele Gly in NNA group, compared with control group. No significance in the frequency of the genotypes and alleles of ~-AR27 loci among the three groups(P ＞0. 05). Conclusion: The Gly16 polymorphism of β2-AR is overrepresented in nocturnal asthmatic patients, correlated with nocturnal asthma and therefore appears to be an important genetic factor in the expression of this asthmatic phenotype.
Keywords：β2-adrenergic receptorgenetic polymorphismnocturnal asthma
Publication Date：2004-08-31
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 235-238 )