Relationship between β3-AR Gene and Obesity, Type 2 Diabetes,Insulin Resistance in Chinese Han Population
HE Wei
MA Xiang-hua
SHEN Jie
Abstract：Objective: To explore the relationship between the β3-adrenergic receptor(β3-AR)gene and obesity,T2DM, insulin resistance in Chinese Han population. Methods: Fifty-three healthy subjects, 105 subjects with simple obesity, 63 type 2 diabetic patients without obesity, and 114 type 2 diabetic patients with obesity were studied with the technique of PCR- RFLP in codon 64 of the exon region of β3-AR gene representing the variation Trp/Arg. Results:Compared with the subjects of Trp homozygous group, the individuals with Arg allele were more elevated in WHR,MBP,SBP, DBP, FBS,PBS, FINS, PINS, FCP, PCP and lower in ISI. Frequency of Arg allele was higher in HINS subgroup without T2DM. Conclusion: The results indicate that the Trp/Arg variation might lead to insulin resistance, obesity and T2DM.β3-AR gene is supposed to be the candidate gene of insulin resistance, obesity and T2DM in Chinese Han population.
Keywords：β3-adrenergic receptor geneobesitytype 2 diabetes mellitusinsulin resistance
Publication Date：2004-07-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 211-214 )