Investigation on Risk Factors of Cerebrocardiac Vascular Thrombotic Diseases in Patients with Obstructive Sleep Apnea Hypopnea Syndrome
Zhang Xi-long
YIN Kai-sheng
SU Mei
HU Ling
Abstract：Objective:To observe the risk factors of thrombosis in patients with obstructive sleep apnea hypopnea syndrome(OSAHS) .Methods: From February 2001 to April 2003, 24 patients with moderate and severe OSAHS (OSAHS group) and 19 healthy adults (control group) were recruited. Their blood samples were drawn at 6:00 and 16:00 respectively for testing hemocrit, platelet aggregation (PAG), whole blood viscosity (WBV), prothrombin time (PT), activated partial thromboplastin time(APlT), plasma fibrinogen (Fng) and endothelin (ET). Results: There was a significantly higher hemocrit, WBV, Fng and ET as well as a significant shortening of PT and APTT at 6:00 than that at 16:00 in OSAHS group However, there was no significant difference in all testing items between 6:00 and 16:00 in control group. The hemocrit, WBV, PAG, plasma Fng and ET were significantly higher, and PT and APTT were obviously shorter at 6:00 in OSAHS group than those at 6:00 in control group. A higher hemocrit, PAG, plasma Fng and ET, a longer PT and APTT were observed at 16:00 in OSAHS group, compared with those at 16:00 in control group. Conclusion: In OSAHS patients there were striking risk factors of thrombosis, which is more remarkable in the early moming than in the aftermoon.
Keywords：Obstructive sleep apnea hypopnea syndromethrombosisstriking risk factors
Publication Date：2004-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 25-28 )