The Effect of Test Dose Fentanyl on Predicting Postoperative Respiratory Depression in Patients with Continuous Intravenous Morphine Analgesia
Abstract：Objective: To evaluate the effect of test dose fentanyl on predicting postoperative analgesia and respiratory depression. Methods: Preoperatively the lowest pulse oximeter saturation ( SpO2 ) under room air breathing was measured after 2μg/kg of fentanyl given intravenously in 35 patients who were scheduled with continuous intravenous morphine analgesia(12μg@kg-1@h-1) postoperatively. Results: The test dose fentanyl resulted in respiratory depression in 19 of 35 cases, while 8 (42.1%) of the 19 cases developed respiratory depression postoperatively. However in the rest 16 patients, no patient (0) developed respiratory depression(P＜0.01 ). The fentanyl-induced lowest SpO2 significantly correlated with the lowest SpO2 postoperatively (P＜0.01). The analgesia effect in terms of verbal analogue scale was correlated neither with the fentanyl-induced lowest SpO2 nor with the lowest SpO2 postoperatively ( P＞0.05). Conclusion: The patient who was sensitive to fentanyl-induced respiratory depression would take a high risk to develop postoperative respiratory depression with intravenous morphine analgesia and the patient with respiratory depression does not always go with satisfactory analgesia.
Keywords：analgesiarespiratory depressionopioidfentanyl test
Publication Date：2003-11-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 283-287,303 )